End-to-End Genome Sequencing Analysis
From DNA to RNA, NVIDIA Clara™ Parabricks delivers powerful acceleration to primary, secondary, and tertiary analyses of genomic data. It does this with turnkey software designed for high-throughput labs on premises or in the cloud and a technology stack that gives developers the ability to build powerful compute tools for genomics.
Based on Broad Institute’s Genome Analysis Toolkit (GATK), NVIDIA Clara Parabricks Pipelines is a ready-to-run, GPU-accelerated software suite for:
DNA Germline variant calling for population genomics DNA Somatic variant calling for cancer genomics and tumor mutational burden (TMB) RNA sequencing projects from whole-transcriptome to single-cell analysis Google’s DeepVariant that enables variant calling using a deep neural network
Optimized for speed, accuracy, and scalability, Clara Parabricks Pipelines can run the GATK4.1 Best Practices and is fully configurable, allowing users to choose which steps, parameter settings, and versions of the pipeline to run.
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Running on NVIDIA A100 Tensor Core GPUs, Clara Parabricks Pipelines delivers unprecedented performance, bringing analysis times down to 23 minutes for DNA Germline variant calling. With GPU acceleration, users can also benefit from reduced cloud computing costs by up to 50 percent when compared to CPU-only solutions.
Germline End-to-End Secondary Analysis
Data was generated using publicly available data for NA 12878 deprecating the data to 30x coverage. For the 23 minute run time, DGX A100 with 320G memory was used. The native GATK4.1 numbers were generated using 32 vCPU [3.1 GHz Intel Xeon® Platinum 8175M] using 128 Gb RAM.
Clara Parabricks Pipelines can be set up in 10 minutes. Use this step-by-step instructional video and start experiencing high-throughput analysis for DNA and RNA sequencing projects.
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Clara Parabricks Pipelines returns results faster than non-GPU-accelerated solutions. Learn how TGEN uses same-day results to investigate the whole genome sequence of healthy and diseased cells to better determine the most effective therapy, personalized to each patient.
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Running in the cloud or on-premise, Clara Parabricks Pipelines can help researchers better understand viral pandemics like COVID-19 faster, from viral evolution to human response to human susceptibility. Watch to learn how.
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Parabricks Pipelines Support Services provides you with an easy, reliable way to improve productivity and reduce system downtime for your production analysis systems. NVIDIA Support services for Parabricks includes:
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A collection of GPU-accelerated edge libraries, reference applications, and open-source applications, the NVIDIA Clara Parabricks Toolkit is created for developers to build AI-assisted workflows for genome analysis. With the toolkit, they can optimize mapping, aligning, and polishing for de novo genome assembly and enhance the resolution of single-cell epigenomics.
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